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272. There is no indication that any thought was given in these particular circumstances to any particular expertise needed to conduct an investigation into alleged sexual harassment. However, this Human Resources Subcommittee was not investigating allegations of sexual harassment. This Human Resources Subcommittee was asked to find out if there was evidence of any connection between EE and five named women, if there was any evidence connecting the five named women and Isaacs. Only if those two questions were to be answered in the affirmative should the “rumours” be tested against the EE policy on sexual harassment and sexual misconduct.

Christo and Jeanne-Claude are at home in Manhattan in a modest loft at an unfashionable edge of SoHo where they have lived for 19 years. Upstairs is the atticlike studio where Christo spends early morning drawing during all the months (even years) when his projects aren’t in the thick of being realized; downstairs is the apartment of the couple’s son, Cyril. Christo is stretched out on the floor, his back propped against a couch, just talking. His conversation is intense, dense, riddled with Bulgarian and prone to French. He is sincere, persuasive, infectiously enthusiastic—and ever so slightly impersonal; another interview is, after all, just one more step in seeing his future projects realized. Talking about his work, he says “we” as often as “I,” almost always including Jeanne-Claude, with whom he has an unusual, symbiotic relationship: She is his dealer, agent, financial manager and curator, as well as his companion of 25 years. Often the plural also includes the engineers and building contractors (particularly Ted Dougherty of A & H Builders, Inc.), lawyers, environmental consultants, local politicians—even active opponents—who help generate the momentum for Christo’s unlikely projects and shape their final realization. It has less to do with modesty than with Christo’s dialectical sense of his creative process. “The work develops its own dimension,” he says. “It is always bigger than my imagination alone.”

352. The report of the Human Resources Subcommittee did make it clear that this was a preliminary investigation, that it was unusual was there was no complainant and that no evidence had been presented of wrongdoing.

This would be the true meaning of sabka saath, sabka vikas. And the 2.3 million women who have been made to suffer abandonment and worse can finally hope for a modicum of justice.

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148. But what has never, to my knowledge, been redacted from the concept of ‘fairness’ are the requirements that a person facing allegations must be put in possession of such information as will enable her/him to make a real response thereto. Anyone against whom allegations are made must have all relevant information disclosed to such person and then giving an opportunity of fully dealing with it. One first needs to have and know the full allegations against oneself and the information upon which they are grounded before one can even attempt to present one’s own information or evidence in response thereto.

Dr. Abuhamad’s team is using these advances in ultrasound to chart placental health in about 500 pregnant women, including 300 at high risk of complications. They are collecting ultrasound data and blood samples from the women at eight time points during pregnancy to see which early features track with problems later on.

Our guide to the top air fryers is based on thorough research into the ratings and experiences of countless experts and users. Based on our analysis, the following models meet the highest standards of reliability, functionality, and value.

207. In his statement, Isaacs dealt with whether or not he had ever flirted with ‘KK’ and acknowledged that he had done so; whether he had transgressed a management meeting decision that Isaacs should not make contact with anyone involved in this case which he acknowledged that he had so transgressed but attached portion of the email to show that he had encouraged the recipient to “answer them [questions] freely” if ever approached; whether he had acted “in a way that leaders should not” and acknowledged that he had learnt “political lessons” which “could embarrass both me and, by extension, EE” and that he had engaged in “risky behavior”. In short, whilst not conceding any transgression of EE policies and procedures, Isaacs did admit to imprudent personal behavior.

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386. That stage was never reached. If the possibility of a disciplinary enquiry or an enquiry into sexual harassment had ever been reached and complaints had been made against Isaacs then the situation may have been different. The Human Resources Subcommittee had already, in their own correspondence, indicated that they envisaged that another disciplinary panel (perhaps from outside the organisation) would have been involved. With this preliminary investigation only, I cannot find any of sufficient reason for recusal from dealing with the first two issues to be dealt with in their terms of reference.

Ratnayake, K et al (2018) Blue light excited retinal intercepts cellular signalling. Scientific Reports 8:10207 DOI:10.1038/s41598-018-28254-8

Volumetric Absorptive Microsampling (VAMS) technology enables accurate samples of blood or other fluids from amounts as small as 10, 20, or 30 microliters, according to Neoteryx, LLC, of Torrance, Calif., the developer of VAMS. The technology is integrated into the company’s Mitra microsampler blood collection devices (shown above) in formats for patient use and for medical laboratory microsample accessioning and extraction. Click here to watch a video on the Mitra Microsampler Specimen Collection Device. (Photo copyright: Neoteryx.)

We present a systematic analysis of MФ–cancer cell fusion and provide evidence that hybrids impart physiologically relevant and functionally significant aspects contributing to tumor evolution. Together, our in vitro and in vivo murine data indicate that neoplastic cells fuse spontaneously with leukocytes and myeloid cells (that is, MФs, neutrophils, or dendritic cells) and produce heterogeneous cancer hybrid clones. Despite their diversity, hybrid clones retain MФ genotypes with functional phenotypes, thereby bestowing MФ-like behaviors on neoplastic cells. Fusion hybrids express functional levels of CSF1R, which is relevant to cancer progression exemplified by the association of CSF1 overexpression in lung cancer with increased tumor cell proliferation and invasion (48), by the inhibition of CSF1R with decreased tumor metastasis (49) and by late-stage metastatic breast carcinomas frequently acquiring CSF1R expression (38). In human tumors, the mechanism by which tumor cells gain chemotactic responsive receptor expression remains unclear, but multiple mechanisms likely underlie transcriptional changes. Our data indicate that cell fusion could play a role in the acquisition of migratory/chemotactic functional behavior and may have important clinical implications considering hybrids’ potential response to clinically relevant CSF1R inhibitors (27, 50, 51).


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