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In contrast, an exhibition of true “secularism” would be open-ended, either agnostic or, at the other extreme, in a country like India where faith is so central, multi-religious. Most importantly, at its heart, true secularism would be driven by universal values of truth, compassion and equality, which are fundamental values that straddle all religions.

Regardless of the best efforts of our elected members, at home and abroad, we must not lose sight of the fact the Cayman’s “A Team” cannot be found on government benches but rather in the financial services industry itself. Cayman’s private sector, understandably, is far more knowledgeable and able in all matters financial than its public representatives, and it is, therefore, paramount that they inform and participate in our strategy going forward ….

b. Achmat had already noted ‘Jane’s’ own reference to being “depressed” on 11th November 2009 and the reason she suggested therefor and when he eventually wrote to her on 17th March 2010 he explained how he had tackled his own depression. This reference to “make-up hiding ‘fears and insecurities” on 17th March 2010 was thus before there was any mention or suggestion of any harassment of ‘Jane’ by anyone at all. It is therefore inexplicable that Achmat could have intended to or made the statements as is alleged in the Mail & Guardian article because there was no complaint made by ‘Jane’ to which Achmat could have so harshly responded.

To evaluate the biological significance of hybrids in humans, we first determined whether hybrids between blood cells and epithelial-derived cancer cells were detectible. To accomplish this, we exploited a disease scenario that supports identification of hybrids harboring properties of peripheral mononuclear blood cells and epithelial cells (30)—specifically, the analysis of tumor biopsies from female cancer patients who had previously received a sex-mismatched bone marrow transplant and subsequently developed a secondary solid tumor. In these patients, only the male donor–transplanted hematopoietic cells should contain a Y chromosome; therefore, identification of Y chromosome–positive nuclei in cytokeratin-positive cells within the tumor biopsy could indicate fusion between a peripheral mononuclear blood cell and an epithelial tumor cell. We identified tumor epithelia by a pathologic review of H&E-stained tumor biopsies, and then we probed tissue sections with pan-cytokeratin antibodies and interrogated with Y chromosome FISH probes to identify cellular products consistent with fusion between neoplastic cells and transplanted male hematopoietic cells (Fig. 5 and fig. S9). In a biopsy from a female patient with pancreatic ductal adenocarcinoma (PDAC), neoplastic cell nuclei containing a Y chromosome were detectible throughout regions of the tumor (Fig. 5, A to E, and fig. S9, A and B), as well as in premalignant regions of pancreatic intraepithelial neoplasia (PanIN; fig. S9C). Confocal microscopy confirmed that Y chromosomes were located in nuclei of cytokeratin-positive epithelial tumor cells (see higher magnifications in Fig. 5). For these studies, tumor specimens from seven patients were examined, and all contained evidence of fusion by these criteria. Y chromosome–positive epithelial tumor cells were not unique to PDAC, as fusion hybrids were detected in other solid tumors from female recipients of sex-mismatched transplantation, including renal cell carcinoma, head and neck squamous cell carcinoma, and lung adenocarcinoma (fig. S9, D to F). Control tissue staining from female and male tissue samples were carried as controls for Y chromosome detection (fig. S10, A and B). These observations were consistent with previous case reports of cell fusion in human cancer using a variety of other detection methods (11, 17, 31, 32).

Thirdly, it took me a long time to overcome serious issues that stemmed from an abusive childhood. This I need to do in my twenties when I had unconditional support from Irshad. Also, I was blessed to have some financial support from Irshad that allowed me time and space to work through what had become debilitating pain. ….

The FDA has approved revefenacin inhalation solution (Yupelri, Theravance Biopharma, Inc./Mylan N.V.) for the maintenance treatment of patients with chronic obstructive pulmonary disease (COPD).

In 21 Lessons for the 21st Century, Yuval Noah Harari captures the essence of these values beautifully. Truth, not to be confused with belief, has no sole custodian. Truth is based on observation, evidence, and inference, and is accessible to all. Compassion comes from an understanding of suffering: a compassionate person does not kill not because their faith tells them not to, but because they know that killing causes immense suffering. And the universal value of equality comes from a recognition of both truth and compassion, empowering people to never substitute “uniqueness” with “superiority”. Everyone may be unique in their own way, but they are all still equally unique — no one being more specially so than the other. Ultimately, we cannot find truth, or learn compassion, or appreciate equality if we have no freedom to think, to question, to seek, to find these for ourselves. These freedoms are, ultimately, the most valuable. Recognising these freedoms was central to the politics of Mahatma Gandhi. Sadly, our leaders since have either forgotten or chosen to turn a blind eye to these ideas completely.

Beware of some cheap CO2 detectors on ebay. Often with no brand name they have been shown not to meet European safety levels. EN 50291 should be listed on the unit for European users. See here for a list of failed units:https://www.carbonmonoxide.ie/htm/co_alarms.htm

At least here in the USA, modern CO2 Detector versions (as with permanent-battery smoke alarms) have a life counter and will go into a failure/alarm mode at the end of their useful life.

5. Although the submissions refer only to non-disclosure to Mr Isaacs and his legal representative, I have enquired of WLC whether these limitations apply also Mr Achmat, Ms Ensor, Dr Geffen, Mr Feinberg, Ms Adler. Absent confirmation from WLC, I have (in order to be prudent) assumed that the restrictions apply to all parties.”

This new indication also applies to fixed-dose combinations of canagliflozin/metformin tablets (Invokamet) and canagliflozin/metformin extended-release tablets (Invokamet XR).

The ongoing phase 3 POLO trial is investigating olaparib as maintenance monotherapy versus placebo. Results from the trial are expected in the first half of 2019.