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249. It must be understood that there is nothing wrong or improper with the co-existence of a private interest (such as friendship or collegiality) when one is required to exercise a public or official duty involving a person with whom one has a private interest. Persons may know each other, have been colleagues for years, have socialized and yet be required to make decisions in a professional or public or official capacity concerning the fate of that other person. For example, South Africa has had notable occasions where the most senior of Judges have presided in opposed litigation where a son or daughter in legal practice has appeared to argue the case – this has not been seen as improper and would only be so if, in fact, the Judge subordinated her or his duty to perform justice and apply the law to the personal affection for and advantage of the offspring.

The FDA granted fast-track designation to PTG-300 (Protagonist Therapeutics), an injectable hepcidin mimetic for the treatment of chronic anemia due to ineffective erythropoiesis in patients with beta-thalassemia, a rare disease characterized by chronic anemia and iron overload.

Eliminating the need to burn stuff in a house – gas or otherwise – does eliminate the possibility of CO poisoning in that house. It would be pretty difficult to get CO in there otherwise.

The blood plasma market report presents in-depth qualitative assessments and quantitative estimations of the blood plasma market. The analyses shed light on the current avenues and emerging frontiers in various application segments of blood plasma. 

In contrast, two allies, albeit smaller ones, Jitan Ram Manjhi and Upendra Kushwaha, have quit and crossed over to the Mahagathbandhan. Given the way the BJP leadership had accommodated the Lok Janshakti Party and a possible repeat appears on the cards vis-a-vis the Apna Dal in Uttar Pradesh, it is evident that the BJP is no longer the dominant force it was in 2014. Back in 2012, when the BJP had few allies and Narendra Modi was asked how he intended to overcome this deficiency in its arsenal, he ascribed the downturn to the party’s winnability declining. “Once we increase our strike rate, the allies will automatically come because of the benefits in being partners with us,” Mr Modi had then said. It is evident that the argument has now turned on its head.

Meltblown nonwovens are relatively inexpensive and existing specifications can be used without the need for expensive and lengthy modification to production protocol. A thermoplastic fibre-forming polymer is extruded via a linear die containing hundreds of small orifices. Convergent streams of hot air rapidly attenuate the extruded polymer streams to form extremely fine diameter fibres which are collected on a conveyor, where an autogenously-bonded meltblown nonwoven is formed. The fibres in the meltblown web are bonded by a combination of entanglement and cohesive sticking.

Chapter 3, to show the focused circumstance among the best producers, with deals, income and piece of the pie in 2017 and 2018;

46. Isaacs informed the Panel that he had never, whilst a management employee, had a relationship with an EE ‘Equaliser’ or member of staff but had done so with two volunteers after their stints as volunteer was concluded. Isaacs also informed the Panel that he had never, whilst Treasurer, had a relationship with an ‘Equaliser’ or a volunteer but had had a romance with an EE staff member in 2016. This relationship came to a close because, although Isaacs (who lived in Johannesburg at that time) only attended National Council meetings three times per annum and went into the EE office perhaps once per month, he thought the existence of the relationship might become complicated. As it was, that staff member left the organization for further studies, this Panel has been in touch with her and she has made no complaint of any sort against Isaacs.

Even as the Constitution was being written, even as the leaders of the independence movement were negotiating for our freedom, Hindutva forces present at the time — the days of the advent of the Hindu Mahasabha, of Veer Savarkar and B.S. Moonje — were suspicious of secular ideas. They were, instead, great admirers of Hitler and Mussolini, with Moonje even going to Italy to meet the latter, and Savarkar justifying Hitler’s treatment of Jews.

Cell fusion between immune and neoplastic cells initiating tumorigenesis and affecting progression is an untested, century-old hypothesis (9, 10) that has been only circumstantially examined (10, 12, 17, 31, 33–37). Reports of cells located in tumors containing components of both immune and neoplastic cells are increasingly frequent (1, 10–13, 16, 17, 19, 35, 38–44), although without strong evidence of etiologic mechanism or physiologic relevance. Early in vitro studies revealed that cell fusion hybrids displayed reduced cell doubling times relative to their genetic burden (45). More recently, it was suggested that tumor cell fusions gain shorter cell cycling times compared to either of their parental cells (46, 47). These divergent views add to the controversy of whether cell fusion provides a selective advantage to evolving tumors. Moreover, description of MФ gene expression in metastatic cancer cells as evidence that fusion propagates aggressive metastatic spread of cancer (31, 42) is presented without substantial proof that these cells arise from a fusion event, further diminishing enthusiasm for this mechanism. Despite this, MФ–neoplastic cell fusion does provide an intriguing mechanism for how neoplastic cells rapidly gain discrete cellular behaviors to facilitate metastases and to propagate intratumoral heterogeneity. Before this study, experimental results demonstrating in vivo tumor cell fusion with MФs or investigating a function role for cell fusion in tumor progression were undetermined. Here, we demonstrate that cell fusion occurs spontaneously in a number of systems. Cell fusion can contribute to the generation of diverse neoplastic clones with altered phenotypes, implicating it as a mechanism for gain of intratumoral heterogeneity. This finding may reveal insight into diverse tumor cell pathophysiology that underlies treatment resistance, progression, and posttreatment tumor recurrence in human cancer.

After the declaration of Prophethood, persecution began. Many tribal leaders, opposed, ridiculed, and even boycotted his clan; Prophet (pbuh) was harassed, assaulted, tortured, and even forced to exile. But Prophet (pbuh) never compromised his moral values. He never displayed anger, never asked for revenge, but always showed most beautiful morality as reported by Ayesha (r.a) mentioned in Tirmidhi that: ‘It was not the nature of Prophet (pbuh) to talk indecently, nor did he engage himself in the use of abhorrent language. Nor did he shout and talk in the bazaars (which is against dignity). He did not avenge a bad deed with a bad one but forgave it, and thereafter did not even mention it’. Who can forget the incident of Taif, in which Prophet (pbuh) and his companion Zaid ibn Muhammad (r.a) faced ill-treatment from pagans. History bears witness; people of Taif threw stones and rocks at Muhammad and his companion, causing them to bleed. The Muhammad (pbuh) bled so profusely from the stoning that his feet congealed to his sandals. Still, Prophet (pbuh) did not utter indecent words against them rather asked Allah for their salvation.

I fear that behind your make-up there is pain and security – do not let it stop you from earning a living (please help SACTWU/Cosatu come into the 21th Century with media), do not let it stop you from becoming an activist leader. [my underlining]