Meltblown nonwovens are relatively inexpensive and existing specifications can be used without the need for expensive and lengthy modification to production protocol. A thermoplastic fibre-forming polymer is extruded via a linear die containing hundreds of small orifices. Convergent streams of hot air rapidly attenuate the extruded polymer streams to form extremely fine diameter fibres which are collected on a conveyor, where an autogenously-bonded meltblown nonwoven is formed. The fibres in the meltblown web are bonded by a combination of entanglement and cohesive sticking.
407. I am surprised and saddened and somewhat mystified by the approach of Professor Manjoo. She knew the Terms of Reference which set the parameters of our duties and she accepted this appointment. She now complains that these are flawed. She participated in all proceedings and knows all the evidence and has had the same opportunity (as have I and Professor Langa) to reduce her views to writing in a manner that will be accessible to all concerned. Those concerned are, not least, Equal Education (which is the organization from which she accepted this appointment) the complainants whose views she wishes to have explored, the persons against whom complaints are made, the cause of justice which she espouses as requiring a transformative approach and a victim centered approach. I am most surprised that it is even possible to accept appointment as a Panellist, hear evidence and argument and then fail to even attempt to express views on the very issues which one claims to consider so vital and significant for our society and not follow through thereon but to simply to resign appointment.
These are consequential responsibilities and, at this moment in Cayman history, all are in need of serious review, if not outright remediation and repair.
Dupilumab (Dupixent, Regeneron/Sanofi) has received FDA approval as an add-on maintenance therapy in patients with moderate-to-severe asthma who are aged 12 years and older with an eosinophilic phenotype or with oral corticosteroid-dependent asthma.
0%? Your suggestion is utterly ridiculous and would (if it wasn’t) imply that science couldn’t work.
249. It must be understood that there is nothing wrong or improper with the co-existence of a private interest (such as friendship or collegiality) when one is required to exercise a public or official duty involving a person with whom one has a private interest. Persons may know each other, have been colleagues for years, have socialized and yet be required to make decisions in a professional or public or official capacity concerning the fate of that other person. For example, South Africa has had notable occasions where the most senior of Judges have presided in opposed litigation where a son or daughter in legal practice has appeared to argue the case – this has not been seen as improper and would only be so if, in fact, the Judge subordinated her or his duty to perform justice and apply the law to the personal affection for and advantage of the offspring.
213. Prior to the actual meeting of the Human Resources Subcommittee, on 10th June 2011, Geffen emailed all other members of that Subcommittee with his concerns as to certain perceived “contradictions” in the sexual harassment section of the EE Code” which Geffen also felt was “generally unclear”81. He points to the contradiction between the penalty of dismissal in the schedule versus the informal procedure which could result in counselling; he finds a circularity in the declaration of a single act to be harassment an queries the position of a “single flirt”; the time periods of three days after reporting did not make sense to him; the procedures for lodging complaints against board members and directors “are not properly laid out” which he views as a serious shortcoming in the future when an elected board would take place when Board members would be in more daily contact with staff. In this case, Geffen’s concerns were not relevant to this particular hearing which concerned the ‘rumours’ but I view Geffen’s detailed commentary on this portion of the Code as indicative of the seriousness and concern with which he and the other members of the Human Resources Subcommittee viewed their responsibilities and approached the Hasson letter and Isaacs’s response thereto.
These data indicate that tumor-initiating hybrid populations can acquire behaviors allowing for navigation of the metastatic cascade—from the primary tumor, to survival in circulation, to seeding of ectopic sites, and to propagation of metastatic foci. Further, in vivo–derived hybrid cells were readily detected in peripheral blood. CHCs outnumbered conventionally isolated CTCs in both mice and humans. Moreover, in patients with pancreatic cancer, CHCs directly correlated with tumor stage and inversely correlated with overall survival—highlighting an exciting prognostic opportunity for development of this novel cell population as a liquid biomarker for disease status in discrete cancers where conventional biomarkers (for example, CTCs, cell-free DNA, exosomes, and proteins) have not demonstrated efficacy.
If approved, ibrutinib with obinutuzumab could become the first chemotherapy-free, anti-CD20 combination for the first-line treatment of CLL/SLL.
215. The first draft of the Report of the Human Resources Subcommittee was considered on the day of the hearing, 11th June and was subsequently amended.83
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